Behavioral and Brain Sciences, Volume 32, Issue 1, February 2009
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Animals were prepared with a bilateral CCI of the frontal cortex.
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A regimen of COG 0. Starting on day 11, the animals were tested for their acquisition of a reference memory task in the Morris water maze MWM , followed by a working memory task in the MWM on day Following CCI, the animals were also tested on the bilateral tactile adhesive removal test to measure sensorimotor dysfunction. On all of the behavioral tests the COG group was no different from the uninjured sham group.
Administration of the regimen of COG significantly improved recovery on the reference and working memory tests, as well as on the sensorimotor test. Lesion analysis revealed that COG significantly reduced the size of the injury cavity. These results suggest that a regimen of COG appeared to block the development of significant behavioral deficits and reduced tissue loss.
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These combined findings suggest that COG appears to have strong preclinical efficacy when administered following traumatic brain injury TBI. Login to your account Username. Forgot password? Keep me logged in. New User. Change Password. Old Password. New Password.
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Enter your email address below and we will send you your username. Journal of Neurotrauma Vol. Michael R. Michael P.
Vitek Cognosci Inc. Suzanne E. McKenna Cognosci Inc. Apolipoprotein E as a novel therapeutic neuroprotection target after traumatic spinal cord injury. Neuroprotective pentapeptide CN is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model. Apolipoprotein E mimetic peptide, CN, improves outcomes in ischemic stroke. Neuroprotective pentapeptide CN improves functional and histological outcomes in a murine model of intracerebral hemorrhage.
A behavioral and histological comparison of fluid percussion injury and controlled cortical impact injury to the rat sensorimotor cortex. Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties.
Todd C. Peterson , Michael R. Finally, important open questions in the field will be summarised. Studied biology at the Ruhr-University Bochum. Her research focus is on the neurobiology of human obesity. Export Citation. User Account Log in Register Help. Search Close Advanced Search Help. Show Summary Details. More options …. Neuroforum Organ der Neurowissenschaftlichen Gesellschaft. Editor-in-Chief: Wahle, Petra. See all formats and pricing.
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